FOXO4-DRI
C₉₃H₁₅₂N₃₀O₂₃
D-retro-inverso peptide studied for selective senescent cell clearance in aging research.
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FOXO4-DRI is a cell-penetrating D-retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells. By blocking this interaction, it promotes p53 nuclear exclusion, triggering apoptosis specifically in senescent cells while sparing healthy cells. Research in aged mice has demonstrated restoration of fitness, fur density, and renal function, making it a landmark compound in senolytic research.
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