
PE-22-28
CββHβ βNβOβ
Spadin analog studied for TREK-1 channel modulation and antidepressant-like effects.
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PE-22-28 is a synthetic peptide analog derived from spadin, a natural inhibitor of the TREK-1 potassium channel. TREK-1 channels are involved in mood regulation, and their inhibition has been associated with antidepressant-like effects. Research has demonstrated rapid-onset mood-modulating activity in animal models, with PE-22-28 showing improved potency and stability compared to the parent spadin molecule.
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