
IGF-1 DES
CβββHβ ββNββ OββSβ
Truncated IGF-1 variant studied for enhanced mitogenic activity and reduced binding protein interference.
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IGF-1 DES (Des(1-3)IGF-1) is a truncated form of insulin-like growth factor-1 missing the first three amino acids. This modification results in reduced binding to IGF binding proteins (IGFBPs), leading to significantly enhanced bioavailability and potency compared to full-length IGF-1. Research has demonstrated 10x greater mitogenic activity, making it a critical tool for studying IGF signaling, cell proliferation, and tissue growth mechanisms.
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