
MGF
CβββHβββNββOββ
Mechano Growth Factor splice variant of IGF-1 studied for muscle satellite cell activation.
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MGF (Mechano Growth Factor) is a splice variant of IGF-1 produced in response to mechanical stress. Unlike systemic IGF-1, MGF acts locally to activate muscle satellite (stem) cells, promoting muscle repair and hypertrophy. Research has focused on its role in exercise-induced muscle adaptation, injury repair, and understanding the local paracrine signaling mechanisms that differentiate it from circulating IGF-1.
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