
MOTS-C
CββHβββNββOββSβ
Mitochondria-derived peptide studied for metabolic regulation and exercise mimetic effects.
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MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a mitochondria-derived peptide encoded within the mitochondrial genome. Research has identified it as a key regulator of metabolic homeostasis, acting as an exercise mimetic by activating AMPK and regulating AICAR metabolism. Studies have demonstrated effects on insulin sensitivity, fat metabolism, and cellular stress resistance, positioning it as a significant target in aging and metabolic research.
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