PNC-27
C₁₅₈H₂₅₅N₄₇O₄₅S₂
HDM-2 binding peptide studied for selective activity against transformed cell lines.
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PNC-27 is a synthetic peptide containing an HDM-2-binding domain conjugated to a membrane-penetrating domain. Research has demonstrated its selective binding to HDM-2 protein overexpressed on the surface of transformed cells, leading to membrane disruption. Crucially, studies show it does not affect untransformed cells, making it a valuable tool for studying selective targeting mechanisms in cancer biology research.
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